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Southwest Florida's Leading Experts in Regenerative Medicine

Discseel® Procedure

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Platelet Rich Plasma

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Stem Cell Therapy

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Prolotherapy

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Ozone Therapy

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Discseel® For Veterans

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Treating Spine, Joint Pain, and Neuropathy by Advanced Regenerative Medicine and Rehabilitation

Our pain treatment and rehabilitation clinic is centrally located in Estero Florida. Servicing Naples, Bonita Springs, Fort Myers, Cape Coral, Boca Raton, Coral Gables, Palm Beach, Fort Lauderdale & Miami Beach

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A non-surgical, whole person approach to pain management, specializing in regenerative treatment for chronic pain.

We are an Integrative Physical Medicine & Rehabilitation clinic located in Estero, FL. We offer a comprehensive team approach to help patients eliminate pain, restore function and achieve a state of health and wellness. By combining advanced regenerative medicine with rehabilitation, nutrition and integrative medicine,  we provide the best healing experience in Southwest Florida.

Patients From Around The World

Learn Why Doctor Sebastian is Leading
the Way in Regenerative Medicine:

Advanced Regenerative Therapy In Southwest Florida

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A Pain Relief Plan Just For You

Finding the right diagnosis is crucial to your treatment – and it’s where everything begins.

Too many patients come to us after years of guessing, trial-and-error treatments, or one-size-fits-all approaches that never addressed the root cause of their pain. We know that no two cases are the same, which is why we never rush to conclusions. From your very first visit, we strive to ensure that each treatment plan is comprehensive and tailored specifically to YOU – not a generic protocol, but a roadmap built around your unique condition, goals, and healing potential.

You’ll receive a thorough evaluation through the integrated lenses of osteopathic, functional, regenerative, and rehabilitative medicine, along with a detailed physical exam where we assess not just the area of pain, but your entire musculoskeletal system, movement patterns, and functional limitations. Only then, with a complete and accurate diagnosis in hand, can we design the most effective regenerative treatment plan to help you heal and get back to the life you want to live.

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Find Relief For Your Symptoms

Back pain relief, shoulder pain relief, knee pain relief…What are your symptoms?

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We are leaders in non-surgical relief for common problems and look at your pain from a holistic, comprehensive approach. We’re here to ensure you heal!

  • Neck Pain Treatment
  • Shoulder Pain Treatment
  • Elbow, Wrist & Hand Pain Treatment
  • Back and Spine Pain Treatment
  • Hip Pain Treatment
  • Knee Pain Treatment
  • Foot & Ankle Pain Treatment
  • Neuropathy Pain Treatment
  • Hypermobility Treatment
Schedule Your Consultation Today

Physical Therapy Compliments our Regenerative Treatment

Regaining your function with Physical Therapy

Therapeutic exercise, designed to improve the patient’s function and decrease disability, differs from traditional exercise as it takes into account the patient’s pain, injuries, and functional impairments. Therapeutic exercise helps to improve the patient’s functional condition and general health, and it is a key part of comprehensive treatment at our practice.

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Recent Blog Posts

Long-Term Results of PRP for Rotator Cuff Tears — Healing That Lasts – Two-Year Study

Study:A 2-year prospective study by Prodromos et al. (2021) examined patients with chronic rotator cuff tendinopathy and variable tears who had not improved with therapy. ...
Read More →

Perineural Platelet-Rich Plasma (PRP) for Diabetic Peripheral Neuropathy — Randomized Trial Shows Durable Benefit

Study:A prospective randomized clinical trial (Hassanien et al., Pain Medicine, 2020) evaluated ultrasound-guided perineural PRP for painful diabetic peripheral neuropathy (DPN). Sixty adults with type ...
Read More →

Adipose-Derived Stem Cells for Rotator Cuff Tears — MRI-Confirmed Tendon Regeneration and Long-Term Improvement

Study:A 2-year prospective study (Jo et al., Arthroscopy, 2020) evaluated the use of autologous adipose-derived stem cells (AD-MSCs) for partial-thickness rotator cuff tears. Nineteen patients ...
Read More →

Long-Term Results of PRP for Rotator Cuff Tears — Healing That Lasts – Two-Year Study

Study:A 2-year prospective study by Prodromos et al. (2021) examined patients with chronic rotator cuff tendinopathy and variable tears who had not improved with therapy. ...
Read More →

Perineural Platelet-Rich Plasma (PRP) for Diabetic Peripheral Neuropathy — Randomized Trial Shows Durable Benefit

Study:A prospective randomized clinical trial (Hassanien et al., Pain Medicine, 2020) evaluated ultrasound-guided perineural PRP for painful diabetic peripheral neuropathy (DPN). Sixty adults with type ...
Read More →
Read More Blog Posts...

What Our Patients Say:

Integrative Rehab Medicine
Based on 159 reviews
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Nicky
I have never left a review regarding a phone call, but there is always a first. I have called this office multiple times asking every question that comes to mind for my husband with back issues. And every time I called I have spoken to Amanda Nagle. She took all of my calls so patiently and kind answering all my questions. I was never rushed most importantly she put me at ease. I have called multiple offices finding a good fit for my husband. And I’m comfortable enough just speaking to, Amanda that this is the right place for him. If the front office “the face of the office” is like this, I know that the rest is amazing.
J H
Anybody going through chronic pain knows the frustration. What did PRP do for me? Pain went from a 9 to a 2 and sometimes 0. Activity? Before I couldn't do anything and was in pain. After, some limitations but no lasting pain. For example, I'm jump roping and running but no load bearing above 30 pounds. It's a learning pain. PRP improved my health. At Integrative Rehab Med. they are absolutely 100% caring and professional. I am thankful for Dr. Sebastian and his professional staff!
Chris Drikakis
I am currently one month removed from my procedure from Dr. Sabastian and his staff. All of my consistent pain stop. Physical therapy is continuing under there direction.

With more positive improvement coming long term my advice why wait call or visit them. Integrative Rehab Medicine is the very best non-surgical treatment of the spinal discs.

I excited about my future living without pain. Make this appointment your health will Thank you later.

Chris Drikakis
A fellow golfer and Vietnam veteran
Response from the owner:Thank you so much, Chris, for taking the time to share your experience—and for your service as a Vietnam veteran. We’re truly honored to be part of your healing journey.

We’re thrilled to hear that just one month after your non-surgical spinal disc procedure, your consistent pain has resolved and that you’re continuing to make progress. At Integrative Rehab Medicine, our mission is to help patients avoid unnecessary spine surgery by offering advanced, evidence-based treatments for chronic back and neck pain, including non-surgical disc repair options such as Discseel® and PRP.

Your story highlights exactly why we focus on treating the underlying cause of disc-related pain—not just masking symptoms—and why so many active patients, including golfers and veterans, seek out non-operative spine care with us. We’re excited about your continued improvement and long-term recovery.

https://irehabmed.com/va

Thank you again for your kind words.
Hernan Mota
Im very fortunate to met the Doctor Sebastian when he came to Margaritaville Cancun riviera Maya. He treated my knee after two surgeries in my right knee without result. The time Doctor Sebastian attended me I was in pain every day and taking anti inflammatory every 2 days, since he treated me my knee and movement change drastically at level I don’t taking any more medication he is a really master pro, for sure I’ll will see him early next year for a second treatment to keep improving my recovery thanks Doctor to came across my live 🙏🙏🙏🙏Hernan Mota
Tom and Margie Hurwich
I had suffered from degenerating discs, bulging discs and arthritis in my lower back for 25 years. I initially went to Integrative Rehab Medicine as they offered DiscSeel, which I heard was a great option for me. Although I was a candidate for this, I opted for PRP and prolotherapy. My recovery was a bit longer than o hoped at 8-12 weeks but I am finally pain free and only get discomfort for a day or so with movements that may have had me down for 2 months. The care in office was wonderful with great follow ups. They also allowed my personal trainer into my physical therapy to ensure we were on the same page with my recovery. Five stars and I would highly recommend.
Response from the owner:Thank you so much for sharing your journey. We truly appreciate your trust after living with degenerative discs, bulging discs, and lumbar arthritis for more than 25 years.
While Discseel® can be an excellent option for certain patients, we’re glad you found success with platelet-rich plasma (PRP) and prolotherapy—two powerful non-surgical treatments designed to reduce inflammation, support tissue healing, and improve spinal stability. As you experienced, biologic spine treatments often require patience, with healing occurring over weeks to months, but the long-term improvement can be life-changing.
We’re especially happy to hear that you’re now pain-free and that movements which once caused months of setback now result in only brief, mild discomfort. That kind of functional recovery is exactly what we aim for at Integrative Rehab Medicine.
We truly appreciate the recommendation and are honored to be part of your long-term spine health.
Genko Ganev
I’m so glad that I found Integraive Rehab Medicine and specifically Dr Sebastian. Dr Sebastian was the only doctor who provided a solution to my damaged lower back that made sense and actually worked. After six months after the procedure I can say that Dr Sebastian gave me back the ability to move pain free and enjoy life as I could at my age. He said he is sorry that he couldn’t make me young again, but he and his staff did a miracle for me.
Thank you Integrative Rehab Medicine for changing my life
Response from the owner:Thank you for sharing your experience and for allowing us to play a role in your healing. We are truly grateful that you put your trust in our regenerative medicine approach to treating back pain and improving function. Helping patients feel stronger and more functional is what we do best here at Integrative Rehab Medicine in Estero, Florida. Take care.
Robert Long
I have not been here but I have seen Dr. Shiple in PA. He is one of the world's most flawless injectors! From PRP, Stellate Ganglion Block, Vagus Nerve Block, Hydrodissection etc...

He has gotten me out of a bedbound life.

He does even better when Bruce Hornsby is playing during the session 😁
Response from the owner:Thank you for sharing such kind words about Dr. Brian Shiple! He is indeed one of the most skilled and experienced regenerative injection specialists in the world, and we’re honored to have him on our team here at Integrative Rehab Medicine in Estero, Florida. It’s inspiring to hear how his advanced techniques—like PRP, Stellate Ganglion Block, Vagus Nerve Block, and ultrasound-guided hydrodissection—helped you reclaim your health and quality of life.
Ryan G
My wife and I traveled from Wisconsin to get my two herniated discs in lower back treated with ozone/prp. I could not be happier with how everything went. Dr. Sebastian and his team are wonderful. From the very beginning of sending in my mri results to after the procedure was so efficient and organized. Everyone at this clinic is very informative, professional and just the nicest people to be around. Especially for me being nervous having never had any back procedures done....they made it so much easier. I am looking forward to my continued healing. You have a raving fan in Wisconsin now and I'd only come to your clinic if I ever need future procedures! Thanks to everyone that helped me!
Response from the owner:Thank you so much for sharing your experience and for traveling all the way from Wisconsin to southwest Florida for your spinal treatments in our Estero clinic. We’re thrilled to hear that your ozone and PRP treatments for herniated discs in your lower back went smoothly and that our team helped you feel comfortable throughout the process. At Integrative Rehab Medicine, we strive to make every step — from MRI review to post-procedure care — efficient, professional, and reassuring. We’re grateful for your trust, excited to see your continued healing, and honored to have a raving fan in Wisconsin!
Alicia
Dr.Sebastian Klisiewicz, was very nice and helpful.He explained my diagnosis very clearly and help me to choose the best treatment for me. Thank you very much for all your help.
Response from the owner:Thank you, Alicia! We’re so glad to hear that you had a positive experience at our Estero clinic. At Integrative Rehab Medicine, we take pride in carefully diagnosing the root cause of pain and offering clear guidance on the best treatment options. It’s wonderful to know you felt supported throughout the process.
P W
2 bouts of pt over 2 years couldn't resolve my back/ leg problem. 1st procedure at IRM: immediate relief within 24 hrs.
Response from the owner:Thank you for sharing your experience! We’re so glad that your first procedure here at our Estero clinic brought such quick relief. At Integrative Rehab Medicine, we specialize in accurately diagnosing the root cause of pain and providing targeted treatments to help patients return to an active, pain-free life.