Southwest Florida's Leading Experts in Regenerative Medicine

Treating Spine, Joint Pain, and Neuropathy by Advanced Regenerative Medicine and Rehabilitation

Our pain treatment and rehabilitation clinic is centrally located in Estero Florida. Servicing Naples, Bonita Springs, Fort Myers, Cape Coral, Boca Raton, Coral Gables, Palm Beach, Fort Lauderdale & Miami Beach

Doctor shows a hologram of a person on a blue background.

A non-surgical, whole person approach to pain management, specializing in regenerative treatment for chronic pain.

We are an Integrative Physical Medicine & Rehabilitation clinic located in Estero, FL. We offer a comprehensive team approach to help patients eliminate pain, restore function and achieve a state of health and wellness. By combining advanced regenerative medicine with rehabilitation, nutrition and integrative medicine,  we provide the best healing experience in Southwest Florida.

Patients From Around The World

Learn Why Doctor Sebastian is Leading
the Way in Regenerative Medicine:

Advanced Regenerative Therapy In Southwest Florida

A Pain Relief Plan Just For You

Finding the right diagnosis is crucial to your treatment – and it’s where everything begins.

Too many patients come to us after years of guessing, trial-and-error treatments, or one-size-fits-all approaches that never addressed the root cause of their pain. We know that no two cases are the same, which is why we never rush to conclusions. From your very first visit, we strive to ensure that each treatment plan is comprehensive and tailored specifically to YOU – not a generic protocol, but a roadmap built around your unique condition, goals, and healing potential.

You’ll receive a thorough evaluation through the integrated lenses of osteopathic, functional, regenerative, and rehabilitative medicine, along with a detailed physical exam where we assess not just the area of pain, but your entire musculoskeletal system, movement patterns, and functional limitations. Only then, with a complete and accurate diagnosis in hand, can we design the most effective regenerative treatment plan to help you heal and get back to the life you want to live.

Photo of a doctor treating a patients shoulder pain

Find Relief For Your Symptoms

Back pain relief, shoulder pain relief, knee pain relief…What are your symptoms?

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We are leaders in non-surgical relief for common problems and look at your pain from a holistic, comprehensive approach. We’re here to ensure you heal!

  • Neck Pain Treatment
  • Shoulder Pain Treatment
  • Elbow, Wrist & Hand Pain Treatment
  • Back and Spine Pain Treatment
  • Hip Pain Treatment
  • Knee Pain Treatment
  • Foot & Ankle Pain Treatment
  • Neuropathy Pain Treatment
  • Hypermobility Treatment

Physical Therapy Compliments our Regenerative Treatment

Regaining your function with Physical Therapy

Therapeutic exercise, designed to improve the patient’s function and decrease disability, differs from traditional exercise as it takes into account the patient’s pain, injuries, and functional impairments. Therapeutic exercise helps to improve the patient’s functional condition and general health, and it is a key part of comprehensive treatment at our practice.

Recent Blog Posts

Long-Term Results of PRP for Rotator Cuff Tears — Healing That Lasts – Two-Year Study

Study:A 2-year prospective study by Prodromos et al. (2021) examined patients with chronic rotator cuff tendinopathy and variable tears who had not improved with therapy. ...
Read More →

Perineural Platelet-Rich Plasma (PRP) for Diabetic Peripheral Neuropathy — Randomized Trial Shows Durable Benefit

Study:A prospective randomized clinical trial (Hassanien et al., Pain Medicine, 2020) evaluated ultrasound-guided perineural PRP for painful diabetic peripheral neuropathy (DPN). Sixty adults with type ...
Read More →

Adipose-Derived Stem Cells for Rotator Cuff Tears — MRI-Confirmed Tendon Regeneration and Long-Term Improvement

Study:A 2-year prospective study (Jo et al., Arthroscopy, 2020) evaluated the use of autologous adipose-derived stem cells (AD-MSCs) for partial-thickness rotator cuff tears. Nineteen patients ...
Read More →

Long-Term Results of PRP for Rotator Cuff Tears — Healing That Lasts – Two-Year Study

Study:A 2-year prospective study by Prodromos et al. (2021) examined patients with chronic rotator cuff tendinopathy and variable tears who had not improved with therapy. ...
Read More →

Perineural Platelet-Rich Plasma (PRP) for Diabetic Peripheral Neuropathy — Randomized Trial Shows Durable Benefit

Study:A prospective randomized clinical trial (Hassanien et al., Pain Medicine, 2020) evaluated ultrasound-guided perineural PRP for painful diabetic peripheral neuropathy (DPN). Sixty adults with type ...
Read More →

What Our Patients Say:

I went to Dr. Sebastian after having 1 year of primarily right sided back pain with mild radiation into my right calf. I wanted to avoid taking medication and surgery. I was active and working out at the gym, but limited in bending, lifting, and running. Dr. Sebastian felt confident my issue was related to an L5-S1 Disc issue and that the Discseel procedure would get me back to the activities that caused pain and eliminate my leg pain.

I had my procedure on June 9, 2025 and every day of my life has been a nightmare ever since. The procedure has caused intense constant nerve pain and burning into both buttocks, thighs, and calves. It caused worse back pain. Simple daily tasks are challenging.

Currently, 1 year later I am severely restricted from bending at all or I get increased burning down my legs. I cannot sit or lift. I cannot walk or stand more than 10 minutes. I have never been able to return to the gym. I have a physical job and I have only been able to work about half of the hours I had before. I am looking at quitting altogether because the hours I do work are excuciating. After unloading my bank account for this procedure, the financial effects of not being able to work are daunting. The physical and mental effects have been devastating. The symptoms have gradually worsened instead of improving and I now have neuropathy pain in my feet. I have had injections, medication, and a consult with a neurosurgeon since then. Discseel promised to keep me from these things, but instead has fast forwarded me toward them.

Looking back, I think they told me about anything to convince me to do the procedure. When I wasn't getting the expected outcomes, they revealed that I had been mislead on many things.
Prior to the procedure, he told me his patients do great with the procedure. Afterwards, he told me story after story of patients who had had failed procedures.
Prior to the procedure, I was told that I had a greater than the average 85% success rate because I was young and active. Afterwards, Dr. Sebastian admitted that its actually been more of his younger more mobile patients who have had failed procedures.
Prior to the procedure, I was told the fibrin was extremely strong and to follow the guidelines, but to not be overly stressed about my movements. Afterwards, Dr. Sebastian said that he has had patients feel a pop in their back and all their symptoms return just from bending over one time, coughing, or sitting on a plane flight.

An MRI post procedure shows I have worse annular tearing and nerve compression at the segment treated than prior.

Aside from something going wrong during the procedure itself, which I am told didnt, I was never warned in any capacity that Discseel could worsen nerve pain and cause worse annular tears and everyone needs to know how risky it is. Worst decision of my life having this done and I would give anything to be at the level of pain I was before I had it. To add insult to injury, after paying thousands of dollars for the procedure they billed my insurance for the follow ups and I was not aware of that. I got a letter saying they would send me to collections over $100 I didnt know I had missed paying. They are making bank off this and the results are not as good as they make you think. DON'T DO IT
Professional, caring, effective
Fantastic alternative to shoulder surgery. My torn tendon is now completely healed. Thank you Floyd, Kristine and your entire team.
Dr. Sebastian and Floyd helped me resolve my arthritic hip issue. I am able to run, sprint, lift weights and exercise intensely on the stair master. At our first meeting we developed a plan and then executed the plan. Everything fell into place from the first of two capsular distension shots. The third shot, a PRP injection just enhanced mobility and made stretching easier while providing a greater range of motion.

I can't thank the IRM Team enough. If you have any type of physical injury, they are the best. They embrace helping athletes!

Thanks again!
I had my Discseel and PRP procedure with Dr. Sebastian at Integrative Rehab Medicine in Estero, Florida, and I truly couldn’t be more grateful for the care I received. From the consultation to the procedure itself, everything was explained clearly and thoroughly. He is extremely knowledgeable and takes a thoughtful, patient-centered approach. He answered all of my questions and made me feel completely comfortable and confident in my decision.

Procedure day went very smoothly. I took a very nice nap thanks to the anesthesia and woke up feeling well cared for by the nurse and supported by the entire team.

I also appreciated how clearly Dr. Sebastian explained the recovery process and set realistic expectations. The office runs efficiently, and you can truly tell they care about their patients and outcomes.

I’m so thankful I found this practice and would highly recommend Dr. Sebastian to anyone considering regenerative treatment options. 🙌🏻
Kris is great 🙂
I want to share my experience not as a patient but as an executive assistant making arrangements for my boss's consultations, procedures and follow up appointments. I dealt with Amanda on a vast array of issues and quite frankly I don't know what I would have done without her. My boss traveled from out of state to Florida so there were a lot of balls in the air to coordinate everything successfully. Amanda always advised me what we needed to do, and she consistently followed up with me to ensure a wonderful experience. She is a true professional and a great asset to the practice.
In June of 2024 I was treated by Dr. Klisiewicz for lumbar degenerative disc disease. Initially, I had a phone consult with the PA and everything went great. We scheduled a date for an epidural PRP and I flew to Florida. Once I arrived is when the problems began. Dr. Klisiewicz said the epidural PRP wouldn't be sufficient and I needed intra-discal -and- epidural PRP, which doubled the cost. Then, he suggested the "gold standard" stem cells, which would then double the price again. It all felt like an upsell. I went with intra-discal and epidural PRP. The only sedation I had was Nitrous and a low dose valium. The procedure was torture. This isn't just me saying it. The web is full of people saying the same thing, including injured combat vets. When I tell other doctors about it, they're astounded. This really should be done under IV sedation. Dr. Klisiewicz also suggested that for the best possible outcome I should do 4 days of the Giga-laser, which I agreed to, mostly to prove a point. I reviewed the PubMed literature. It's a big stretch to claim this laser any effect on low back pain. This is an 18 watt laser, and at the wavelengths used, it will only effect a few millimeters of tissue. This is far far less than necessary to effect tissues as deep as the lumbar spine. PubMed data on the Giga-laser is mixed, at best. When I asked Dr. Klisiewicz about this, he had a deer in the headlight look and deflected the conversation. That was the second big red flag. My Giga-laser appointments were every morning at 8am EDT, because I had work commitments at 8am CDT and only had one hour. On one of the days, Dr. Klisiewicz suggested I do PT with them every morning. Again, it felt like another upsell that wasn't discussed prior to me flying to Florida. When I said I couldn't, he commented "well if those are your priorities". Excuse me!! This comment was extremely insulting. There's a difference between 'commitments' and 'priorities'. I'm sure he'd rather spend his day with his family, but he has -commitments- to his patients and staff. Similarly, I had -commitments-. That comment was red flag number 3 and really what motivated me to leave a poor review.

While there are some studies that show PRP does work for some people, I had no benefit. Some studies do show that multiple treatments are more beneficial, but I refused to return. For me, this experience was a waste of time and money.

Lastly, I understand Dr. Klisiewicz is doing Discseel combined with PRP. This hasn't been studied in clinical trials. This is just inventing medicine and can be dangerous. That's not my opinion. That's the comment of several doctors familiar with the procedures. Even Discseel only works in 1/2 the patients. This data comes from the doctor who created the procedure. "At the 12-month follow-up, 50% of patients achieved minimal clinically important differences...".

The only reason I gave 2 stars is because of his nursing staff. They're great. If it weren't for them, this would be a zero star review.
I have never left a review regarding a phone call, but there is always a first. I have called this office multiple times asking every question that comes to mind for my husband with back issues. And every time I called I have spoken to Amanda Nagle. She took all of my calls so patiently and kind answering all my questions. I was never rushed most importantly she put me at ease. I have called multiple offices finding a good fit for my husband. And I’m comfortable enough just speaking to, Amanda that this is the right place for him. If the front office “the face of the office” is like this, I know that the rest is amazing.
Anybody going through chronic pain knows the frustration. What did PRP do for me? Pain went from a 9 to a 2 and sometimes 0. Activity? Before I couldn't do anything and was in pain. After, some limitations but no lasting pain. For example, I'm jump roping and running but no load bearing above 30 pounds. It's a learning pain. PRP improved my health. At Integrative Rehab Med. they are absolutely 100% caring and professional. I am thankful for Dr. Sebastian and his professional staff!