Southwest Florida's Leading Experts in Regenerative Medicine

Treating Spine, Joint Pain, and Neuropathy by Advanced Regenerative Medicine and Rehabilitation

Our pain treatment and rehabilitation clinic is centrally located in Estero Florida. Servicing Naples, Bonita Springs, Fort Myers, Cape Coral, Boca Raton, Coral Gables, Palm Beach, Fort Lauderdale & Miami Beach

Doctor shows a hologram of a person on a blue background.

A non-surgical, whole person approach to pain management, specializing in regenerative treatment for chronic pain.

We are an Integrative Physical Medicine & Rehabilitation clinic located in Estero, FL. We offer a comprehensive team approach to help patients eliminate pain, restore function and achieve a state of health and wellness. By combining advanced regenerative medicine with rehabilitation, nutrition and integrative medicine,  we provide the best healing experience in Southwest Florida.

Patients From Around The World

Learn Why Doctor Sebastian is Leading
the Way in Regenerative Medicine:

Advanced Regenerative Therapy In Southwest Florida

A Pain Relief Plan Just For You

Finding the right diagnosis is crucial to your treatment – and it’s where everything begins.

Too many patients come to us after years of guessing, trial-and-error treatments, or one-size-fits-all approaches that never addressed the root cause of their pain. We know that no two cases are the same, which is why we never rush to conclusions. From your very first visit, we strive to ensure that each treatment plan is comprehensive and tailored specifically to YOU – not a generic protocol, but a roadmap built around your unique condition, goals, and healing potential.

You’ll receive a thorough evaluation through the integrated lenses of osteopathic, functional, regenerative, and rehabilitative medicine, along with a detailed physical exam where we assess not just the area of pain, but your entire musculoskeletal system, movement patterns, and functional limitations. Only then, with a complete and accurate diagnosis in hand, can we design the most effective regenerative treatment plan to help you heal and get back to the life you want to live.

Photo of a doctor treating a patients shoulder pain

Find Relief For Your Symptoms

Back pain relief, shoulder pain relief, knee pain relief…What are your symptoms?

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We are leaders in non-surgical relief for common problems and look at your pain from a holistic, comprehensive approach. We’re here to ensure you heal!

  • Neck Pain Treatment
  • Shoulder Pain Treatment
  • Elbow, Wrist & Hand Pain Treatment
  • Back and Spine Pain Treatment
  • Hip Pain Treatment
  • Knee Pain Treatment
  • Foot & Ankle Pain Treatment
  • Neuropathy Pain Treatment
  • Hypermobility Treatment

Physical Therapy Compliments our Regenerative Treatment

Regaining your function with Physical Therapy

Therapeutic exercise, designed to improve the patient’s function and decrease disability, differs from traditional exercise as it takes into account the patient’s pain, injuries, and functional impairments. Therapeutic exercise helps to improve the patient’s functional condition and general health, and it is a key part of comprehensive treatment at our practice.

Recent Blog Posts

Long-Term Results of PRP for Rotator Cuff Tears — Healing That Lasts – Two-Year Study

Study:A 2-year prospective study by Prodromos et al. (2021) examined patients with chronic rotator cuff tendinopathy and variable tears who had not improved with therapy. ...
Read More →

Perineural Platelet-Rich Plasma (PRP) for Diabetic Peripheral Neuropathy — Randomized Trial Shows Durable Benefit

Study:A prospective randomized clinical trial (Hassanien et al., Pain Medicine, 2020) evaluated ultrasound-guided perineural PRP for painful diabetic peripheral neuropathy (DPN). Sixty adults with type ...
Read More →

Adipose-Derived Stem Cells for Rotator Cuff Tears — MRI-Confirmed Tendon Regeneration and Long-Term Improvement

Study:A 2-year prospective study (Jo et al., Arthroscopy, 2020) evaluated the use of autologous adipose-derived stem cells (AD-MSCs) for partial-thickness rotator cuff tears. Nineteen patients ...
Read More →

Long-Term Results of PRP for Rotator Cuff Tears — Healing That Lasts – Two-Year Study

Study:A 2-year prospective study by Prodromos et al. (2021) examined patients with chronic rotator cuff tendinopathy and variable tears who had not improved with therapy. ...
Read More →

Perineural Platelet-Rich Plasma (PRP) for Diabetic Peripheral Neuropathy — Randomized Trial Shows Durable Benefit

Study:A prospective randomized clinical trial (Hassanien et al., Pain Medicine, 2020) evaluated ultrasound-guided perineural PRP for painful diabetic peripheral neuropathy (DPN). Sixty adults with type ...
Read More →

What Our Patients Say:

I had my Discseel and PRP procedure with Dr. Sebastian at Integrative Rehab Medicine in Estero, Florida, and I truly couldn’t be more grateful for the care I received. From the consultation to the procedure itself, everything was explained clearly and thoroughly. He is extremely knowledgeable and takes a thoughtful, patient-centered approach. He answered all of my questions and made me feel completely comfortable and confident in my decision.

Procedure day went very smoothly. I took a very nice nap thanks to the anesthesia and woke up feeling well cared for by the nurse and supported by the entire team.

I also appreciated how clearly Dr. Sebastian explained the recovery process and set realistic expectations. The office runs efficiently, and you can truly tell they care about their patients and outcomes.

I’m so thankful I found this practice and would highly recommend Dr. Sebastian to anyone considering regenerative treatment options. 🙌🏻
Kris is great 🙂
I want to share my experience not as a patient but as an executive assistant making arrangements for my boss's consultations, procedures and follow up appointments. I dealt with Amanda on a vast array of issues and quite frankly I don't know what I would have done without her. My boss traveled from out of state to Florida so there were a lot of balls in the air to coordinate everything successfully. Amanda always advised me what we needed to do, and she consistently followed up with me to ensure a wonderful experience. She is a true professional and a great asset to the practice.
In June of 2024 I was treated by Dr. Klisiewicz for lumbar degenerative disc disease. Initially, I had a phone consult with the PA and everything went great. We scheduled a date for an epidural PRP and I flew to Florida. Once I arrived is when the problems began. Dr. Klisiewicz said the epidural PRP wouldn't be sufficient and I needed intra-discal -and- epidural PRP, which doubled the cost. Then, he suggested the "gold standard" stem cells, which would then double the price again. It all felt like an upsell. I went with intra-discal and epidural PRP. The only sedation I had was Nitrous and a low dose valium. The procedure was torture. This isn't just me saying it. The web is full of people saying the same thing, including injured combat vets. When I tell other doctors about it, they're astounded. This really should be done under IV sedation. Dr. Klisiewicz also suggested that for the best possible outcome I should do 4 days of the Giga-laser, which I agreed to, mostly to prove a point. I reviewed the PubMed literature. It's a big stretch to claim this laser any effect on low back pain. This is an 18 watt laser, and at the wavelengths used, it will only effect a few millimeters of tissue. This is far far less than necessary to effect tissues as deep as the lumbar spine. PubMed data on the Giga-laser is mixed, at best. When I asked Dr. Klisiewicz about this, he had a deer in the headlight look and deflected the conversation. That was the second big red flag. My Giga-laser appointments were every morning at 8am EDT, because I had work commitments at 8am CDT and only had one hour. On one of the days, Dr. Klisiewicz suggested I do PT with them every morning. Again, it felt like another upsell that wasn't discussed prior to me flying to Florida. When I said I couldn't, he commented "well if those are your priorities". Excuse me!! This comment was extremely insulting. There's a difference between 'commitments' and 'priorities'. I'm sure he'd rather spend his day with his family, but he has -commitments- to his patients and staff. Similarly, I had -commitments-. That comment was red flag number 3 and really what motivated me to leave a poor review.

While there are some studies that show PRP does work for some people, I had no benefit. Some studies do show that multiple treatments are more beneficial, but I refused to return. For me, this experience was a waste of time and money.

Lastly, I understand Dr. Klisiewicz is doing Discseel combined with PRP. This hasn't been studied in clinical trials. This is just inventing medicine and can be dangerous. That's not my opinion. That's the comment of several doctors familiar with the procedures. Even Discseel only works in 1/2 the patients. This data comes from the doctor who created the procedure. "At the 12-month follow-up, 50% of patients achieved minimal clinically important differences...".

The only reason I gave 2 stars is because of his nursing staff. They're great. If it weren't for them, this would be a zero star review.
Anybody going through chronic pain knows the frustration. What did PRP do for me? Pain went from a 9 to a 2 and sometimes 0. Activity? Before I couldn't do anything and was in pain. After, some limitations but no lasting pain. For example, I'm jump roping and running but no load bearing above 30 pounds. It's a learning pain. PRP improved my health. At Integrative Rehab Med. they are absolutely 100% caring and professional. I am thankful for Dr. Sebastian and his professional staff!
I have seen spinal surgeons, orthopedic surgeons, neurologists, and gotten trigger point injections. Nothing made my chronic low back pain better. Once I went to Dr. Sebastian and his clinic, they reviewed my MRIs and X-Rays, did a physical assessment, and quickly identified my issue in the first visit. I was hesitant to continue with the PRP procedure in my pelvis and low back, since I have been in constant pain for 11 months and had many failures with injections. I am now a little over 2 months post-PRP procedure, back to running and lifting with no pain. I am extremely grateful for Dr. Sebastian and his entire staff, who were welcoming and supportive every day I came into the clinic!
Response from the owner:Thank you for trusting Integrative Rehab Medicine in Estero, Florida with your back pain care. We understand how discouraging chronic low back pain can be after seeing multiple specialists without relief. We’re glad that a comprehensive assessment allowed Dr. Sebastian Klisiewicz to identify the source of your, and better yet, an effective back pain treatment with PRP injections and specific rehabilitation. Hearing that you’re back to running and lifting pain-free just over two months after your PRP procedure is incredibly rewarding. Our team is committed to providing care in a safe environment while supporting our patients every step of the way. We’re grateful to be part of your recovery and wish you continued health and strength.
I am currently one month removed from my procedure from Dr. Sabastian and his staff. All of my consistent pain stop. Physical therapy is continuing under there direction.

With more positive improvement coming long term my advice why wait call or visit them. Integrative Rehab Medicine is the very best non-surgical treatment of the spinal discs.

I excited about my future living without pain. Make this appointment your health will Thank you later.

Chris Drikakis
A fellow golfer and Vietnam veteran
Response from the owner:Thank you so much, Chris, for taking the time to share your experience—and for your service as a Vietnam veteran. We’re truly honored to be part of your healing journey.

We’re thrilled to hear that just one month after your non-surgical spinal disc procedure, your consistent pain has resolved and that you’re continuing to make progress. At Integrative Rehab Medicine, our mission is to help patients avoid unnecessary spine surgery by offering advanced, evidence-based treatments for chronic back and neck pain, including non-surgical disc repair options such as Discseel® and PRP.

Your story highlights exactly why we focus on treating the underlying cause of disc-related pain—not just masking symptoms—and why so many active patients, including golfers and veterans, seek out non-operative spine care with us. We’re excited about your continued improvement and long-term recovery.

https://irehabmed.com/va

Thank you again for your kind words.
As a medical professional ( anesthesiology) for 40 years Dr Sebastian helped me avoid debilitating back surgery with a six week recovery ( which I scheduled for ) two weeks before my Ozone/ lysated platelet epidural. I am beyond the moon happy with my results. His office is very professional and his PT therapist Christine is also excellent !
Response from the owner:Thank you so much for sharing your experience. Coming from a medical professional with over 40 years in anesthesiology, your perspective truly means a great deal to our entire team.
We’re thrilled to hear that your ozone intradiscal treatment combined with lysated platelet (PRP) epidural injections helped you avoid a major back surgery and a prolonged recovery. At Integrative Rehab Medicine, we love helping patients with herniated and bulging discs find effective, non-surgical alternatives to spine surgery.
Your outcome highlights the power of biologic and regenerative spine treatments—using ozone to reduce disc inflammation and herniation, along with platelet-based therapies to support healing around irritated spinal nerves. We’re also glad to hear your experience with Kristine, our physical therapist, has complemented your recovery.
Thank you again for your words and confidence in our team.
Im very fortunate to met the Doctor Sebastian when he came to Margaritaville Cancun riviera Maya. He treated my knee after two surgeries in my right knee without result. The time Doctor Sebastian attended me I was in pain every day and taking anti inflammatory every 2 days, since he treated me my knee and movement change drastically at level I don’t taking any more medication he is a really master pro, for sure I’ll will see him early next year for a second treatment to keep improving my recovery thanks Doctor to came across my live 🙏🙏🙏🙏Hernan Mota
I had suffered from degenerating discs, bulging discs and arthritis in my lower back for 25 years. I initially went to Integrative Rehab Medicine as they offered DiscSeel, which I heard was a great option for me. Although I was a candidate for this, I opted for PRP and prolotherapy. My recovery was a bit longer than o hoped at 8-12 weeks but I am finally pain free and only get discomfort for a day or so with movements that may have had me down for 2 months. The care in office was wonderful with great follow ups. They also allowed my personal trainer into my physical therapy to ensure we were on the same page with my recovery. Five stars and I would highly recommend.
Response from the owner:Thank you so much for sharing your journey. We truly appreciate your trust after living with degenerative discs, bulging discs, and lumbar arthritis for more than 25 years.
While Discseel® can be an excellent option for certain patients, we’re glad you found success with platelet-rich plasma (PRP) and prolotherapy—two powerful non-surgical treatments designed to reduce inflammation, support tissue healing, and improve spinal stability. As you experienced, biologic spine treatments often require patience, with healing occurring over weeks to months, but the long-term improvement can be life-changing.
We’re especially happy to hear that you’re now pain-free and that movements which once caused months of setback now result in only brief, mild discomfort. That kind of functional recovery is exactly what we aim for at Integrative Rehab Medicine.
We truly appreciate the recommendation and are honored to be part of your long-term spine health.