Long-Term Results of PRP for Rotator Cuff Tears — Healing That Lasts – Two-Year Study
Study:A 2-year prospective study by Prodromos et al. (2021) examined patients with chronic rotator cuff tendinopathy and variable tears who had not improved with therapy. Seventy-one shoulders were treated with dual-site PRP injections into the tendon and joint capsule. Their pain (VAS Score), function (Quick DASH), and global improvement were evaluated at 6, 12, and […]
Perineural Platelet-Rich Plasma (PRP) for Diabetic Peripheral Neuropathy — Randomized Trial Shows Durable Benefit
Study:A prospective randomized clinical trial (Hassanien et al., Pain Medicine, 2020) evaluated ultrasound-guided perineural PRP for painful diabetic peripheral neuropathy (DPN). Sixty adults with type 2 diabetes and at least 6 months of symptomatic DPN were randomized to PRP plus standard medical therapy vs medical therapy alone. Outcomes included pain VAS, numbness VAS, modified Toronto […]
Adipose-Derived Stem Cells for Rotator Cuff Tears — MRI-Confirmed Tendon Regeneration and Long-Term Improvement
Study:A 2-year prospective study (Jo et al., Arthroscopy, 2020) evaluated the use of autologous adipose-derived stem cells (AD-MSCs) for partial-thickness rotator cuff tears. Nineteen patients received ultrasound-guided intratendinous injections of AD-MSCs. They were followed for 2-years and evaluated for pain, strength, function and tendon healing on MRI. Results: Shoulder pain decreased by approximately 90% at […]
Bone Marrow Stem Cells are a Non-Surgical Option for Rotator Cuff Tears — with Sustained 2-Year Improvement
Study:A randomized controlled crossover trial (Centeno et al., 2020) compared ultrasound-guided injections of autologous bone marrow concentrate (BMC) combined with PRP to a structured home exercise program for patients with partial and full-thickness supraspinatus tears who had failed at least 3 months of conservative care. Patients were followed for up to 24 months using DASH […]
Ozone for Lumbar Disc Herniation — High-Volume Study Supports a Safe, Minimally Invasive Option
For patients with lumbar and cervical disc herniations, ozone disc nucleolysis offers a targeted, image-guided solution to reduce disc pressure and inflammatory radiculopathy without surgery. Study:A retrospective analysis from a multi-center team in India (Ghatge et al., 2023) followed 2,089 patients (3,762 treated discs) with lumbar disc herniation and radicular pain who had not improved […]
Fibrin Discseel Procedure Demonstrates Long-Term Back Pain and Sciatica Relief Through Disc Healing — 3-Year Study Results
Study:A landmark study published in Pain Physician (Pauza et al., 2024) evaluated 827 patients with chronic low back pain lasting over six months (average duration 11 years). All patients had failed at least four prior invasive treatments, such as epidural or facet steroid injections, PRP or stem cell therapy, radiofrequency ablation, and even spinal surgery, […]
PRP is Better than Steroids for Rotator Cuff Tears —Providing Pain Relief and Functional Improvement
Study:A randomized controlled trial (Thepsoparn et al., 2021) compared PRP to steroid injections in 31 patients with partial-thickness rotator cuff tears who had failed months of conservative therapy. Patients were randomized to receive an ultrasound-guided injection of either PRP into the tendon tear or corticosteroids into the subacromial bursa (it is contraindicated to inject steroids […]
PRP Can Heal Rotator Cuff Tears — Proven by MRI to Promote True Tendon Healing Study
A recent randomized controlled trial (Tanpowpong et al., 2023) investigated 29 patients with symptomatic partial-thickness tears of the supraspinatus tendon who had failed ≥3 months of conservative treatment. Participants were randomized to receive either an ultrasound-guided PRP injection into the tear or a steroid injection into the subacromial space. The tear size was evaluated with […]
Discogenic Back Pain from Leaky Discs and the Fibrin Glue Solution
Article at a Glance: Spinal injuries can disrupt the collagen fibers in the annulus, leading to annular tears and disc degeneration. Injured and painful spinal discs contain elevated inflammatory cytokines, which drive discogenic pain and accelerate degeneration. Leaky Disc Syndrome occurs when annular tears allow inflammatory proteins to leak out, triggering chronic pain and inflammation. […]